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Immunofixation Electrophoresis Urine (Ife)

₹8,500.00

15 minutes
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Immunofixation Electrophoresis (IFE) of urine is a laboratory test used to detect and identify abnormal proteins, particularly monoclonal immunoglobulins (M-proteins or paraproteins), in the urine. These proteins are often produced in excess by abnormal plasma cells and can be associated with disorders like multiple myeloma or Waldenström’s macroglobulinemia.
In this test:
• Urine proteins are first separated by electrophoresis based on their size and charge.
• Then, specific antibodies are applied to bind to immunoglobulin components (IgG, IgA, IgM, kappa, lambda).
• The presence of monoclonal (M) protein bands is identified by visualizing the antibody-bound proteins.
It is more sensitive than standard electrophoresis and is especially useful for detecting small amounts of abnormal immunoglobulins.

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    Description

    Why It’s Done:
    This test is commonly done to:
    • Detect and identify monoclonal proteins in the urine.
    • Diagnose and monitor plasma cell disorders, such as:
    o Multiple myeloma
    o Light chain (Bence Jones) myeloma
    o Amyloidosis
    o Monoclonal gammopathy of undetermined significance (MGUS)
    • Monitor disease progression or response to treatment.
    Urine IFE is often used alongside serum IFE and 24-hour urine protein tests for a complete assessment.

    Preparation:
    • Sample required: A 24-hour urine collection is usually preferred for accuracy, although a random urine sample may be used in some cases.
    • No fasting or dietary restrictions are typically needed.
    • Ensure no contamination of the urine sample during collection.
    • Inform your doctor of any medications or supplements you’re taking, as some may interfere with results.
    • Follow all instructions provided for 24-hour urine collection, including storing the sample properly

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