Description
Why It’s Done:
The Serum Protein Electrophoresis test is typically done to:
• Diagnose and monitor multiple myeloma and related plasma cell disorders.
• Identify immune system problems such as monoclonal gammopathy of undetermined significance (MGUS) or primary amyloidosis.
• Evaluate unexplained symptoms: Like fatigue, weakness, bone pain, weight loss, or recurrent infections.
• Investigate chronic inflammation or infections.
• Monitor autoimmune diseases: Like lupus or rheumatoid arthritis.
• Assess liver or kidney diseases: That can affect blood protein levels.
Abnormal results may show a monoclonal protein spike (M-spike) or other distinctive patterns pointing toward specific conditions.
Preparation:
• Fasting: Fasting is generally not required unless specifically instructed by your doctor.
• Medication disclosure: Inform your healthcare provider about any medications, supplements, or recent treatments, as certain drugs (like corticosteroids) can influence protein levels.
• Avoid recent vaccinations or infections: Ideally, the test should not be performed during an acute infection or soon after vaccination, as these can temporarily affect results.
• Stay hydrated: Normal hydration helps with accurate blood sample collection.
