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Pnh By Gel Lda Technique

₹2,000.00

15 minutes
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The PNH by Gel LDA (Lactate Dehydrogenase Activity) Technique test is a specialized diagnostic test used to detect Paroxysmal Nocturnal Hemoglobinuria (PNH), a rare and serious blood disorder. In PNH, red blood cells break down prematurely, leading to hemolysis, which is the destruction of red blood cells.

The Gel LDA technique involves measuring the activity of lactate dehydrogenase (LDH), an enzyme that is released when red blood cells break down. Elevated LDH levels can be an indication of hemolysis, a key feature of PNH.

This test is used to detect and confirm PNH by evaluating the breakdown of red blood cells in the bloodstream and the presence of abnormal red blood cell clones.

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    Description

    Why It’s Done
    The PNH by Gel LDA Technique test is typically ordered to:
    • Diagnose PNH: It helps detect hemolysis, a hallmark of PNH, and is used to confirm the presence of the disease.
    • Evaluate unexplained anemia or fatigue: PNH can lead to symptoms like fatigue, pallor, abdominal pain, and dark-colored urine (particularly in the morning), so this test is used to investigate unexplained symptoms.
    • Monitor disease progression: In patients already diagnosed with PNH, the test can be used to monitor disease activity, including the extent of hemolysis.
    • Identify hemolysis in suspected cases of PNH: In cases where PNH is suspected based on clinical signs (e.g., dark urine or symptoms of hemolytic anemia), this test can help confirm the diagnosis.
    • Evaluate LDH levels: Elevated LDH levels are often seen in hemolytic anemias, including PNH, making it a useful marker for tracking disease activity.

    Preparation
    • Fasting: In general, fasting is not required for the PNH by Gel LDA test. However, you should follow your doctor’s specific instructions regarding fasting, if necessary.
    • Medications: Inform your doctor about any medications you are taking, as some drugs may influence test results. Certain drugs can affect LDH levels, so your doctor may advise you to temporarily stop medications before the test if needed.
    • Blood sample: The test requires a blood sample, which is typically drawn from a vein in your arm.
    • Timing: This test may be done during times of symptoms or flare-ups, as the activity of PNH can vary over time. It may also be repeated for monitoring purposes.

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