Description
Why It’s Done:
The Liver Kidney Microsome Autoantibodies (LKM) Test is typically performed to:
• Diagnose autoimmune hepatitis: The presence of LKM antibodies is a hallmark of type 2 autoimmune hepatitis. This autoimmune disorder causes chronic inflammation of the liver, which can lead to cirrhosis or liver failure if left untreated. The LKM test can help confirm the diagnosis.
• Assess liver injury or damage: The test can be used to investigate unexplained liver dysfunction, especially in cases where the liver damage might be due to an autoimmune process rather than viral infections or alcohol-related damage.
• Identify drug-induced liver injury: Certain medications can trigger the development of autoantibodies, including LKM antibodies. The test can help determine if drugs like isoniazid (used to treat tuberculosis) or minocycline (an antibiotic) are contributing to liver damage.
• Monitor disease progression: In individuals diagnosed with autoimmune hepatitis or other autoimmune conditions, the LKM test may be used to monitor disease activity and response to treatment.
Preparation:
• Fasting: Typically, no fasting is required for the LKM test.
• Blood sample collection: A blood sample will be drawn from a vein in your arm to detect LKM autoantibodies.
• Inform your healthcare provider about any current medications or supplements you are taking, as some drugs (such as minocycline or isoniazid) can affect the results by triggering autoimmune responses in the liver.
• Symptoms and medical history: Be sure to inform your healthcare provider about any liver disease symptoms (e.g., fatigue, jaundice, abdominal pain) or history of autoimmune conditions.
• Timing: If you’re undergoing treatment for a known liver disease or autoimmune condition, your healthcare provider may recommend the test to assess the effectiveness of treatment or disease progression.
