Lipoprotein Electrophoresis

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Lipoprotein electrophoresis is a laboratory test used to separate and identify different types of lipoproteins in the blood based on their electrical charge and size. Lipoproteins are particles that transport cholesterol and triglycerides through the bloodstream. This test distinguishes between major lipoprotein classes such as:
• Chylomicrons
• VLDL (Very Low-Density Lipoprotein)
• LDL (Low-Density Lipoprotein)
• HDL (High-Density Lipoprotein)
The test is often used to detect lipoprotein abnormalities that may be linked to inherited lipid disorders or risk of cardiovascular disease.

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    Description

    Why It’s Done:
    Lipoprotein electrophoresis is performed to:
    • Diagnose genetic lipid disorders, such as familial hypercholesterolemia or familial combined hyperlipidemia.
    • Evaluate abnormal results from a standard lipid panel.
    • Help assess the risk of atherosclerosis and cardiovascular disease.
    • Investigate causes of premature heart disease, especially when family history is significant.
    • Classify types of hyperlipoproteinemia (increased levels of lipoproteins in the blood).

    Preparation:
    • Fasting for 12–14 hours is typically required before the test.
    o Only water is allowed during this fasting period.
    • Avoid alcohol and high-fat meals the day before the test.
    • Inform your doctor about:
    o Any medications or supplements you are taking, especially lipid-lowering agents, estrogens, or steroids, as these can influence lipoprotein levels.
    • Follow any additional instructions provided by your healthcare provider.