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Ihc – Undifferentiated Tumor Panel # 2 (Pan Ck, Lca, S-100, Desmin)

₹5,000.00

15 minutes
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The IHC – Undifferentiated Tumor Panel #2 is an immunohistochemistry (IHC) panel used to identify the tissue origin of undifferentiated or poorly differentiated tumors, which are tumors that do not clearly show their lineage under standard microscopic examination. This panel includes four key markers:

• Pan CK (Cytokeratin): Detects epithelial origin, indicating carcinoma.
• LCA (Leukocyte Common Antigen): Identifies lymphoid cells, used to diagnose lymphoma.
• S-100: Expressed in neural, melanocytic, and some soft tissue tumors, like melanoma and schwannoma.
• Desmin: A muscle-specific marker, indicating myogenic origin, often seen in rhabdomyosarcoma or leiomyosarcoma.

By examining the expression of these markers, this panel helps in distinguishing between carcinomas, lymphomas, melanomas, and muscle-derived sarcomas.

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    Description

    Why It’s Done:
    This panel is used to:
    • Diagnose tumors of uncertain origin when the cell type is not clearly identified.
    • Differentiate between major tumor categories (epithelial, lymphoid, neural, and muscle).
    • Guide further testing or treatment, as therapies vary significantly by tumor type.
    • Support histological diagnosis when morphology alone is inconclusive.

    Preparation:
    • Sample required: Tissue biopsy or surgical tumor specimen.
    • No special preparation (e.g., fasting or medication restrictions) is needed from the patient.
    • The specimen is processed in the laboratory and stained with antibodies targeting the four markers.
    • Clinical history, imaging reports, and preliminary diagnosis should be provided to the lab for accurate interpretation.

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