Ihc – Follicular Lymphoma Panel : (Cd3, Cd5, Cd10, Cd20, Bcl- 2)

6,000.00

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The Follicular Lymphoma Panel is a set of Immunohistochemistry (IHC) tests used to detect specific cell surface and intracellular markers in lymphoid tissue. This panel helps in diagnosing and classifying follicular lymphoma and distinguishing it from other lymphoid malignancies.

The panel includes the following markers:
• CD3: A marker for T-cells; used to identify and exclude T-cell lineage.
• CD5: Typically found on T-cells and some B-cell lymphomas (like mantle cell lymphoma); helps differentiate between lymphoma subtypes.
• CD10: A germinal center B-cell marker, commonly positive in follicular lymphoma.
• CD20: A B-cell marker, indicating the presence of mature B-lymphocytes.
• BCL-2: An anti-apoptotic protein; abnormally expressed in follicular lymphoma cells, helping to distinguish them from reactive follicles (which are BCL-2 negative).

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    Description

    Why It’s Done:

    This panel is performed to:
    • Diagnose follicular lymphoma, one of the most common types of indolent non-Hodgkin lymphomas.
    • Differentiate between reactive follicular hyperplasia (benign) and follicular lymphoma (malignant).
    • Classify lymphoma subtypes based on immunophenotypic profiles.
    • Guide treatment planning and predict disease behavior based on marker expression.
    The pattern of marker expression (e.g., CD10+, BCL-2+, CD5−, CD3−) supports a diagnosis of follicular lymphoma.

    Preparation:

    • No special preparation is required from the patient.
    • The test is performed on a tissue sample, typically obtained through lymph node biopsy or excision.
    • If undergoing a biopsy, your doctor may provide specific instructions such as:
    o Fasting (if sedation or anesthesia is needed)
    o Stopping certain medications
    o Arranging transportation after the procedure
    Follow all pre-procedure instructions provided by your healthcare provider.