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Ihc – Bcl-2

₹2,000.00

15 minutes
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The BCL-2 test uses Immunohistochemistry (IHC) to detect the expression of the BCL-2 protein in tissue samples. BCL-2 is an anti-apoptotic protein, meaning it helps cells resist programmed cell death (apoptosis). Overexpression of BCL-2 is associated with various cancers, particularly certain lymphomas and breast cancers, and can indicate resistance to chemotherapy.

The test helps pathologists analyze whether cancer cells are producing excessive BCL-2 protein, which may influence the tumor’s behavior and response to treatment.

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    Description

    Why It’s Done:

    The IHC – BCL-2 test is typically performed to:
    • Diagnose and classify lymphomas, especially follicular lymphoma, diffuse large B-cell lymphoma, and others.
    • Assess prognosis in certain cancers—BCL-2 positivity may be associated with more aggressive or treatment-resistant disease.
    • Guide treatment decisions, especially in hematologic cancers and breast cancer.
    • Differentiate between reactive and neoplastic lymphoid proliferations.

    Preparation:

    • No special preparation is needed from the patient.
    • The test is conducted on a biopsy or surgical tissue sample, often from lymph nodes or tumors.
    • Pre-biopsy instructions (such as fasting or pausing certain medications) may be necessary depending on the biopsy method.
    • Inform your doctor about any current medications or medical history before undergoing the biopsy procedure.

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