Cryptococcus Ag

2,500.00

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The Cryptococcus Antigen (CrAg) Test is a highly sensitive and specific laboratory test used to detect Cryptococcus neoformans or Cryptococcus gattii antigens in body fluids such as:
• Cerebrospinal fluid (CSF)
• Blood (serum or plasma)
• Sometimes urine or bronchoalveolar lavage fluid
This test identifies polysaccharide antigens from the fungal capsule, helping to diagnose cryptococcal infection, especially cryptococcal meningitis. It is more reliable than the India Ink test and can detect the infection even in early stages.
It can be performed using techniques such as:
• Lateral flow assay (LFA) (rapid and point-of-care)
• Latex agglutination
• Enzyme immunoassay (EIA)

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    Description

    Why It’s Done:

    This test is primarily done to:
    • Diagnose cryptococcal meningitis, particularly in HIV-positive or immunocompromised individuals.
    • Detect systemic cryptococcosis, which may affect the lungs, blood, or other organs.
    • Screen high-risk patients, such as those with advanced HIV/AIDS, for asymptomatic infection before it becomes severe.
    • Monitor response to treatment in known cryptococcal infections.
    Symptoms leading to testing may include:
    • Headache
    • Fever
    • Neck stiffness
    • Confusion or disorientation
    • Blurred vision
    • Seizures (in CNS involvement)
    • Respiratory symptoms (if lung involvement is suspected)

    Preparation:

    • No special preparation is usually needed.
    • If CSF is required, it will be collected by a lumbar puncture; you may need to lie flat afterward to reduce the risk of headache.
    • For blood tests, a routine blood draw is performed; no fasting is necessary.
    • Inform your doctor of any current medications, especially antifungals or immunosuppressants.
    • Follow any specific instructions provided by your healthcare provider.
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