Description
Why It’s Done:
This test is typically ordered to:
• Diagnose Cushing’s syndrome (overproduction of cortisol).
• Help identify Addison’s disease (underproduction of cortisol).
• Evaluate symptoms such as unexplained weight gain, muscle weakness, high blood pressure, excessive hair growth, irregular periods, fatigue, or low blood sugar.
• Monitor adrenal gland function or effectiveness of treatment for adrenal disorders.
Preparation:
• No fasting is required, but follow your healthcare provider’s instructions carefully.
• Avoid vigorous physical activity and stress before and during the collection period, as these can increase cortisol levels.
• Inform your doctor of all medications and supplements, especially:
o Corticosteroids
o Oral contraceptives
o Anti-seizure drugs
• You will be given a large container to collect all your urine over a 24-hour period.
o Start the collection in the morning: Discard the first urine of the day, then collect all urine for the next 24 hours, including the first urine of the next morning.
o Keep the container refrigerated or on ice during collection.
