B – Cell Clonality For Igh

5,000.00

The B-Cell Clonality for IGH (Immunoglobulin Heavy Chain) Test is a molecular diagnostic test used to detect clonal rearrangements in the immunoglobulin heavy chain gene (IGH) of B lymphocytes. This test helps determine whether a population of B-cells is monoclonal (originating from a single cell clone) or polyclonal (normal, diverse population).
Clonality testing is performed using PCR-based methods to amplify IGH gene segments and analyze their patterns. It is widely used in diagnosing B-cell lymphomas and leukemias, where clonal B-cell proliferation is a hallmark.

Description

Why It’s Done:

This test is done to:
• Diagnose and classify B-cell lymphoproliferative disorders, such as:
o Non-Hodgkin lymphoma
o Chronic lymphocytic leukemia (CLL)
o Other B-cell malignancies
• Differentiate between benign/reactive lymphoid hyperplasia (polyclonal) and malignant lymphoma (monoclonal)
• Monitor disease progression or relapse after treatment
• Assist in evaluating unclear lymph node biopsies or blood/marrow samples

Preparation:

• No special preparation such as fasting is required.
• A sample of tissue, blood, bone marrow, or other relevant specimen is collected depending on the clinical indication.
• Inform your healthcare provider about any recent treatments or medications.
• The procedure for sample collection depends on the source (e.g., biopsy, blood draw