Description
Purpose of the Test:
• Detect clonal T-cell receptor gene rearrangements
• Help diagnose T-cell lymphomas, including cutaneous T-cell lymphoma (CTCL) and T-cell acute lymphoblastic leukemia (T-ALL)
• Differentiate between malignant and benign/reactive T-cell expansions
• Monitor minimal residual disease (MRD) or relapse
What the Test Involves:
• A sample of blood, bone marrow, lymph node tissue, or skin biopsy is collected
• Polymerase Chain Reaction (PCR) is used to amplify TCR gene segments
• A monoclonal pattern suggests a neoplastic process, while a polyclonal pattern suggests a reactive process
