Description
Why It’s Done
The Free PSA test is typically recommended to:
• Evaluate elevated total PSA levels (usually between 4–10 ng/mL).
• Help differentiate between prostate cancer and non-cancerous prostate enlargement.
• Support decision-making on whether a prostate biopsy is necessary.
Lower free PSA percentage may indicate a higher risk of prostate cancer.
Higher free PSA percentage suggests a lower cancer risk, more likely due to benign conditions.
Preparation
• Avoid ejaculation for 24–48 hours before the test (may raise PSA levels).
• No digital rectal exam (DRE) for 24 hours prior, if possible (can temporarily elevate PSA).
• Inform your doctor about any medications or supplements, especially:
o 5-alpha reductase inhibitors (like finasteride)
o Hormonal treatments
• Fasting is not required.
• A blood sample is taken from a vein in your arm.


