Description
Why It’s Done:
The Protein C Activity test may be ordered for the following reasons:
• Diagnose Protein C deficiency: To identify inherited or acquired Protein C deficiency, which can cause an increased tendency for blood clots (thrombophilia).
• Investigate unexplained blood clots: Especially in young patients or those with a family history of clotting disorders.
• Evaluate clotting risk: In patients with repeated deep vein thrombosis (DVT), pulmonary embolism, or clotting problems without an obvious cause.
• Monitor liver function: Since Protein C is produced in the liver, abnormal levels may also provide information about liver health.
Preparation:
• Fasting: Fasting is not usually required unless specified by your healthcare provider.
• Medication disclosure: Inform your doctor about all medications and supplements you are taking. Some blood thinners (like warfarin) and other medications can affect Protein C levels.
• Timing: The test is often postponed if you are currently experiencing an acute clotting event or are on anticoagulant therapy, as these conditions can affect results.
• Avoid recent clotting events: Ideally, testing should be done at least a few weeks after a clotting event or after discontinuation of anticoagulants for accurate results (your doctor will advise the timing).


