Description
Why It’s Done:
This test is primarily used to help diagnose neurological conditions involving immune system dysfunction. Key uses include:
• Diagnosing Multiple Sclerosis (MS): One of the most common reasons for this test; the presence of OCBs in CSF but not in serum supports the diagnosis of MS.
• Detecting CNS infections such as viral or bacterial meningitis or neurosyphilis.
• Identifying inflammatory or autoimmune disorders of the CNS, like neurolupus or neurosarcoidosis.
• Monitoring progression or recurrence of certain neurologic conditions.
Preparation:
• No specific preparation is required before the test.
• The test involves a lumbar puncture (spinal tap) to collect CSF:
o You may be asked to lie still in a curled or sitting position.
o Local anesthesia is usually administered to reduce discomfort.
o You might be advised to rest for a few hours afterward to avoid post-lumbar puncture headache.
• Inform your doctor if you:
o Take blood thinners or anticoagulants.
o Have any bleeding disorders.
o Are pregnant or have spine-related conditions.
