Description
Why It’s Done:
The Metanephrine 24-hour urine test is typically performed to:
• Diagnose pheochromocytoma or paraganglioma (tumors of the adrenal glands or sympathetic nervous system) that may cause symptoms like high blood pressure, headaches, sweating, or rapid heart rate.
• Monitor patients with diagnosed pheochromocytoma or paraganglioma to check the effectiveness of treatment or surgery.
• Evaluate high blood pressure (hypertension) when the cause is uncertain or when secondary causes (like adrenal gland tumors) are suspected.
• Help determine if elevated levels of catecholamines or their metabolites are causing unexplained symptoms such as:
o Severe headaches
o Sweating
o Elevated blood pressure or heart rate
o Panic attacks
Preparation:
• Collect urine over a 24-hour period, following these guidelines:
o Start by discarding the first urine sample in the morning.
o Collect all subsequent urine in the provided container for the next 24 hours, including the first urine sample the following morning.
o Refrigerate the urine sample or keep it cool during the collection period to prevent changes in the urine composition.
• Avoid certain foods, beverages, and medications that can interfere with the results, including:
o Caffeine (found in coffee, tea, and chocolate)
o Alcohol
o Tyramine-rich foods (e.g., aged cheese, fermented foods)
o Certain medications (such as decongestants, antidepressants, and blood pressure medications), so inform your healthcare provider about any medications you are taking.
• Avoid stress and vigorous physical activity before and during the collection period, as they may temporarily elevate catecholamine levels.
• Ensure adequate hydration, but avoid drinking excessive amounts of water.
