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Immunofixation Electrophoresis Serum(Ife)

₹7,000.00

15 minutes
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Immunofixation Electrophoresis (IFE) of serum is a highly sensitive laboratory test used to detect, identify, and characterize monoclonal immunoglobulins (also known as M-proteins or paraproteins) in the blood. These abnormal proteins are produced by clonal plasma cells and are commonly associated with plasma cell disorders.

The test works in two stages:
1. Electrophoresis separates proteins in the serum based on size and electrical charge.
2. Immunofixation involves applying antibodies against immunoglobulin heavy chains (IgG, IgA, IgM) and light chains (kappa, lambda) to identify any abnormal monoclonal proteins.
It is more sensitive and specific than standard serum protein electrophoresis (SPEP).

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    Description

    Why It’s Done:
    The Serum IFE test is typically performed to:
    • Diagnose and classify plasma cell disorders, such as:
    o Multiple Myeloma
    o Waldenström’s Macroglobulinemia
    o Monoclonal Gammopathy of Undetermined Significance (MGUS)
    o Primary Amyloidosis (AL type)
    • Detect small monoclonal proteins that may be missed by SPEP.
    • Monitor treatment response or disease progression in known plasma cell disorders.
    • Differentiate between polyclonal (normal immune response) and monoclonal (abnormal) immunoglobulin patterns.

    Preparation:
    • Sample required: Blood sample (serum).
    • No fasting or special preparation is needed.
    • Inform your healthcare provider about:
    o Any medications or supplements you’re taking.
    o Any known or suspected immune system disorders.
    o Recent infections or vaccinations, which can affect protein levels.

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