Description
Why It’s Done:
The test is commonly used to:
• Detect oligoclonal bands (OCBs) in CSF, a key marker for multiple sclerosis (MS).
• Differentiate between systemic and CNS-specific antibody production (by comparing with serum IFE).
• Help diagnose other inflammatory, infectious, or neoplastic CNS disorders, such as:
o Neurosarcoidosis
o CNS lymphoma
o Chronic infections (e.g., neurosyphilis, Lyme disease)
Preparation:
• Sample required: Cerebrospinal fluid obtained via lumbar puncture (spinal tap).
• Patient preparation:
o Fasting is not required, but the procedure involves specific precautions.
o The patient may be asked to lie flat for some time after the lumbar puncture.
• A serum sample is often collected at the same time for comparison with CSF to distinguish systemic vs. intrathecal antibody production.
• Inform your healthcare provider about:
o Current medications
o Bleeding disorders or use of blood thinners
o Any symptoms related to neurological disorders
