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Ihc – Undifferentiated Tumor Panel # 1 (Pan Ck, Lca, S-100, Vimentin)

₹5,000.00

15 minutes
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The IHC – Undifferentiated Tumor Panel #1 is a diagnostic tool used to evaluate undifferentiated or poorly differentiated tumors where the cell type is unclear under a microscope. This test uses a set of immunohistochemical markers to determine the lineage or origin of tumor cells, helping to identify whether a tumor is of epithelial, lymphoid, neural, or mesenchymal origin.

This panel includes:
• Pan CK (Cytokeratin): Detects epithelial cells, commonly positive in carcinomas.
• LCA (Leukocyte Common Antigen): Indicates lymphoid lineage, used to detect lymphomas.
• S-100: Marker for neural, melanocytic, and some soft tissue tumors like melanoma and schwannoma.
• Vimentin: A marker of mesenchymal origin, often seen in sarcomas and some other non-epithelial tumors.

These markers help differentiate between carcinomas, lymphomas, melanomas, and sarcomas, which can appear similar under routine histology.

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    Description

    Why It’s Done:
    This test is typically ordered when:
    • A tumor appears undifferentiated or ambiguous on routine histopathology.
    • There is a need to determine the tumor’s origin to guide further testing or treatment.
    • The clinician or pathologist needs to narrow down a broad differential diagnosis for a suspected malignancy.
    • It’s essential to choose appropriate therapies, especially when targeted treatments are available based on tumor type.

    Preparation:
    • Sample required: Tissue biopsy or surgical specimen from the tumor.
    • No patient preparation such as fasting is necessary.
    • The specimen is processed in the lab and stained with antibodies specific to the four markers.
    • It is recommended to provide the pathologist with clinical history, imaging findings, and provisional diagnosis for accurate interpretation.

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