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Ihc – Spindle Cell Tumour (Pan Ck, Lca, S100, Vimentin, Hmb- 45)

₹5,000.00

15 minutes
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This test uses Immunohistochemistry (IHC) to evaluate spindle cell tumors, which are tumors composed of elongated cells resembling fibroblasts or smooth muscle cells. These tumors can be benign or malignant and arise from various tissues like mesenchymal, epithelial, neural, or melanocytic origin.

The test involves a panel of markers to differentiate between tumor types:
• Pan CK (Cytokeratin): Identifies epithelial origin, seen in sarcomatoid carcinoma.
• LCA (Leukocyte Common Antigen): Suggests lymphoid origin, seen in lymphomas.
• S100: Marks neural, melanocytic, and some soft tissue tumors like schwannoma and melanoma.
• Vimentin: A general marker for mesenchymal cells, positive in most spindle cell sarcomas.
• HMB-45: A melanocytic marker, positive in malignant melanoma.

This combination helps pathologists determine the origin of spindle cell tumors more accurately

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    Description

    Why It’s Done:
    This test is performed to:
    • Diagnose and classify spindle cell tumors based on their origin.
    • Differentiate between sarcoma, carcinoma, melanoma, and lymphoma.
    • Guide appropriate treatment, as management varies significantly by tumor type.
    • Support or confirm histological findings from standard microscopy.

    Preparation:
    • Sample required: Tissue biopsy or surgical specimen from the tumor.
    • No special patient preparation is required (no fasting or medication changes).
    • The sample is stained in the laboratory using specific antibodies for the markers listed.
    • It’s helpful to provide the lab with relevant clinical details and imaging reports for accurate interpretation.

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