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Ihc – Round Cell Tumour (Children) : (Nse, Lca, Cd 99, Vimentin, Desmin)

₹6,000.00

15 minutes
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This test uses Immunohistochemistry (IHC) to analyze pediatric round cell tumors, a group of aggressive and undifferentiated small, round cell malignancies seen in children. IHC helps identify the tumor type by using specific markers:

• NSE (Neuron-Specific Enolase): Indicates neuroendocrine or neural origin, commonly used in neuroblastoma.
• LCA (Leukocyte Common Antigen): Helps identify lymphoid origin, often used to detect lymphomas.
• CD99: Strongly expressed in Ewing sarcoma/PNET.
• Vimentin: A marker of mesenchymal origin.
• Desmin: Indicates muscle differentiation, seen in rhabdomyosarcoma.

By identifying the expression pattern of these markers, pathologists can narrow down the diagnosis and differentiate between tumors like neuroblastoma, Ewing sarcoma, lymphoma, rhabdomyosarcoma, etc.

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    Description

    Why It’s Done:
    This test is performed to:
    • Diagnose the specific type of small round cell tumor in children.
    • Guide treatment planning, since different tumors require different therapies.
    • Predict prognosis, as some tumors are more aggressive than others.
    • Confirm or rule out differential diagnoses based on morphology.

    Preparation:
    • Sample required: Tissue biopsy (already taken during surgery or biopsy procedure).
    • No fasting or special dietary preparation is needed from the patient.
    • The sample is processed in the laboratory using antibodies specific to the markers mentioned.
    • Clinical history and imaging reports should ideally accompany the tissue for accurate interpretation.

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