Description
Why It’s Done:
• To diagnose neuroendocrine tumors (NETs): The IHC – NSE test is often used to diagnose and classify neuroendocrine tumors, including those that originate in the lungs, gastrointestinal tract, or pancreas. Small cell lung cancer and neuroblastomas are examples of tumors that may produce high levels of NSE.
• To differentiate between types of cancer: Elevated NSE levels in tissue may help distinguish between neuroendocrine tumors and other types of cancers that present with similar symptoms but do not express NSE.
• To monitor tumor activity and response to treatment: For patients with neuroendocrine tumors, NSE levels can be used to monitor disease progression or response to treatment. A decrease in NSE after treatment may indicate that the tumor is responding well, while increasing levels may suggest recurrence or metastasis.
• To identify metastatic disease: NSE can also be useful in detecting metastasis (spread) of neuroendocrine tumors to other areas of the body, particularly the lungs, liver, or bone.
Preparation:
• Fasting: Fasting is generally not required for the IHC – NSE test.
• Tissue sample: The test requires a tissue biopsy, typically obtained from a suspected neuroendocrine tumor in organs like the lungs, gastrointestinal tract, pancreas, or lymph nodes. The sample is typically collected via fine needle aspiration or surgical biopsy.
• Medications: Inform your healthcare provider about any medications you are currently taking, particularly those related to chemotherapy, radiation, or hormonal therapies, as these treatments may influence tumor behavior and the production of NSE.
• No special preparation: There are generally no dietary or lifestyle changes required before the test. However, specific instructions regarding the biopsy procedure should be followed.
