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Ihc – Cd 117 (C-Kit)

₹2,000.00

15 minutes
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CD117, also known as c-Kit, is a transmembrane tyrosine kinase receptor that plays a role in cell signaling, proliferation, and survival. This Immunohistochemistry (IHC) test detects the presence of CD117 protein in tissue samples, using specific antibodies that bind to the protein.
CD117 is normally found on hematopoietic stem cells, mast cells, melanocytes, and germ cells, but it is also expressed in various tumors. The test is particularly useful in identifying:

• Gastrointestinal stromal tumors (GISTs)
• Mast cell disorders (e.g., systemic mastocytosis)
• Some cases of acute myeloid leukemia (AML)
• Other tumors such as seminomas, melanoma, and certain sarcomas

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    Description

    Why It’s Done:

    This test is used to:
    • Diagnose and confirm GISTs, as CD117 is a key diagnostic marker (positive in ~95% of cases).
    • Guide targeted therapy decisions — for example, patients with CD117-positive GISTs may respond to tyrosine kinase inhibitors like imatinib.
    • Differentiate between tumor types, particularly when diagnosing spindle cell tumors or small round blue cell tumors.
    • Identify mast cell neoplasms or evaluate some hematologic malignancies (e.g., AML).

    Preparation:

    • No special preparation is required from the patient.
    • The test is conducted on a tissue sample obtained via biopsy or surgical resection.
    • If a biopsy is planned, your doctor may provide specific instructions (e.g., regarding food, drink, or medications).

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