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Ihc – B Cell Phenotypes : (Cd3, Cd15, Cd20, Cd30, Cd45, Ro, Igm)

₹8,500.00

15 minutes
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The IHC – B Cell Phenotypes test uses Immunohistochemistry (IHC) to evaluate lymphoid tissue for the presence and characteristics of B-cell populations. It employs a panel of specific antibodies (markers) to detect protein expression on cell surfaces and within tissues, helping to classify lymphoid cells and identify B-cell-related lymphomas.

Markers Included:
• CD3: Marker for T-cells, used to differentiate T-cells from B-cells.
• CD15: Often expressed in classical Hodgkin’s lymphoma.
• CD20: Key marker for B-lymphocytes.
• CD30: Expressed in activated B- and T-cells; also in Hodgkin’s lymphoma.
• CD45: Pan-leukocyte marker; identifies hematopoietic origin.
• RO (CD45RO): Memory T-cell marker; helps differentiate T-cell subtypes.
• IgM (Immunoglobulin M): Antibody produced by B-cells; indicates B-cell lineage and activity.

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    Description

    Why It’s Done:

    This test is primarily used to:
    • Identify B-cell populations and differentiate them from T-cell populations.
    • Classify lymphomas, especially B-cell non-Hodgkin lymphomas.
    • Distinguish between reactive and malignant lymphoid conditions.
    • Support diagnosis of specific lymphoma subtypes, such as follicular lymphoma, diffuse large B-cell lymphoma, or Hodgkin’s lymphoma.
    • Aid in treatment planning and prognosis assessment.

    Preparation:

    • No special preparation is needed for the IHC test itself.
    • The test is performed on a tissue sample, usually obtained through a lymph node or tissue biopsy.
    • Follow any pre-biopsy instructions provided by your doctor, such as fasting or medication adjustments.
    • Inform your physician about any medications, allergies, or medical history relevant to the biopsy procedure.

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