Ihc – Adenocarcinoma V/S Mesothelioma (Ber Ep4, Hmbe-1)

2,500.00

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This test uses Immunohistochemistry (IHC) to differentiate between adenocarcinoma (a type of cancer that originates in glandular tissue) and mesothelioma (a cancer of the mesothelial lining, often related to asbestos exposure). The panel includes two markers:

• Ber-EP4: Typically positive in adenocarcinoma and negative in mesothelioma.
• HBME-1 (Human Mesothelial Cell 1): Typically positive in mesothelioma and negative or weak in adenocarcinoma.

By detecting the expression of these markers in tissue samples, the test helps pathologists distinguish between the two malignancies, which can appear similar under a microscope.

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    Description

    Why It’s Done:

    This test is ordered when there is a need to:
    • Differentiate between adenocarcinoma and mesothelioma, especially in cases involving pleural or peritoneal tumors.
    • Provide a definitive diagnosis to guide appropriate treatment.
    • Aid in the classification of malignant pleural effusions or biopsies from serous membranes.
    • Determine prognosis and therapeutic approach, since treatment strategies differ significantly between the two cancers.

    Preparation:

    • No special preparation is typically required for the IHC test itself.
    • A biopsy is necessary to obtain tissue for testing. This may be from the pleura, peritoneum, or another affected site.
    • Pre-biopsy instructions may include fasting or medication adjustments, depending on the procedure type.
    • Inform your healthcare provider about any ongoing medications, allergies, or underlying health conditions.