Description
Why It’s Done:
The IgA serum test is performed to:
1. Evaluate Immune System Function:
o Low levels of IgA can indicate an IgA deficiency, which can leave the body more susceptible to infections, particularly in the respiratory and gastrointestinal systems.
o High levels of IgA can be seen in some chronic infections, autoimmune diseases, and certain cancers.
2. Diagnose IgA Deficiency:
o IgA deficiency is the most common primary immune deficiency. Individuals with IgA deficiency may have recurrent respiratory and gastrointestinal infections, and may also experience allergic disorders.
3. Monitor Autoimmune Diseases:
o Elevated IgA levels are sometimes associated with autoimmune diseases such as lupus, rheumatoid arthritis, or inflammatory bowel disease (IBD).
4. Detect Certain Cancers:
o Increased IgA levels may be associated with multiple myeloma, Waldenström’s macroglobulinemia, or other types of lymphoma.
5. Assess for Celiac Disease:
o Although not the primary test, IgA serum testing can also be used as part of the diagnostic workup for celiac disease, as some individuals with celiac disease may have low levels of IgA.
6. Investigate Chronic Infections:
o Some infections, such as hepatitis, HIV, or mononucleosis, may affect IgA levels, which this test can help monitor.
Preparation:
• No special preparation is typically required for the IgA serum test.
• The test is done using a blood sample drawn from a vein in your arm.
• It is important to inform your healthcare provider of any medications or supplements you are currently taking, as certain drugs can affect IgA levels.
o Medications like immunosuppressants and corticosteroids may lower IgA levels, while antibiotics or vaccinations may temporarily alter IgA responses.
• Fasting is generally not required, but follow any specific instructions from your healthcare provider
