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Her 2 Neu By Fish

₹12,000.00

15 minutes
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The HER2/neu by FISH (Fluorescence In Situ Hybridization) test is a molecular diagnostic test used to detect amplification of the HER2/neu gene in cancer cells, most commonly in breast cancer and some gastric cancers.
HER2 (Human Epidermal growth factor Receptor 2) is a gene that produces a protein promoting the growth of cancer cells. In about 15–20% of breast cancers, this gene is overexpressed or amplified, which may lead to more aggressive tumor growth.
FISH is a technique that uses fluorescent probes to bind to specific parts of the HER2 gene in a sample of cancer tissue, allowing visualization under a special microscope. It is considered more precise than immunohistochemistry (IHC) when determining HER2 status.

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    Description

    Why It’s Done:

    The HER2/neu by FISH test is performed to:
    • Determine if a breast cancer or gastric cancer is HER2-positive.
    • Help guide treatment decisions, especially regarding targeted therapies such as trastuzumab (Herceptin), pertuzumab, or lapatinib.
    • Confirm ambiguous or borderline results from a HER2 IHC test (e.g., IHC score of 2+).
    • Evaluate prognosis, as HER2-positive cancers tend to be more aggressive but may respond well to targeted therapy.

    Preparation:

    • No special preparation is required from the patient.
    • The test is performed on a sample of tumor tissue, usually obtained through:
    o Biopsy
    o Surgical removal of the tumor
    • The tissue is then processed in a lab for analysis using FISH.

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