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Coombs Test Direct/Dat

₹500.00

15 minutes
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The Direct Coombs Test, also known as the Direct Antiglobulin Test (DAT), is a blood test used to detect antibodies or complement proteins that are bound to the surface of red blood cells. These antibodies or proteins may cause the immune system to attack and destroy red blood cells—a process called hemolysis.
In the test, a sample of the patient’s red blood cells is mixed with Coombs reagent (antihuman globulin). If the red blood cells are coated with antibodies or complement, the Coombs reagent will cause the cells to clump (agglutinate), indicating a positive result.

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    Description

    Why It’s Done:

    The Direct Coombs Test is typically ordered to:
    • Diagnose autoimmune hemolytic anemia, where the immune system attacks its own red blood cells.
    • Investigate causes of unexplained hemolysis (red blood cell destruction).
    • Evaluate hemolytic disease of the newborn (HDN) when a baby has jaundice or anemia.
    • Assess transfusion reactions when a patient develops symptoms after receiving a blood transfusion.
    • Monitor patients with conditions like lupus or certain cancers that may cause immune-related hemolysis.

    Preparation:

    • No special preparation is usually needed for this test.
    • Inform your doctor about any medications or supplements you are taking, as certain drugs can interfere with the results or cause drug-induced hemolysis.
    • The test is done using a blood sample, typically drawn from a vein in your arm.

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