Description
Why It’s Done:
This test is commonly used to:
• Screen for and diagnose multiple myeloma
• Monitor the progression or response to treatment in patients with:
o Multiple myeloma
o Waldenström’s macroglobulinemia
o Light chain amyloidosis
• Detect monoclonal gammopathies (abnormal protein production)
• Evaluate unexplained proteinuria, bone pain, anemia, or kidney dysfunction
The presence of Bence Jones protein is a key marker for multiple myeloma and may indicate damage to the kidneys.
Preparation:
• The test requires a 24-hour urine collection:
o Discard the first urine of the day.
o Collect all urine for the next 24 hours, including the first urine of the next morning.
o Use the container provided by your lab or doctor.
• Keep the urine container refrigerated or as instructed during the collection period.
• Inform your doctor about any medications or supplements you’re taking, as some may interfere with test results.
• No special diet or fasting is usually needed unless instructed otherwise


