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Bcr – Abl Qualitative / Philadelphia Chromosome

₹5,000.00

15 minutes
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The BCR-ABL Qualitative Philadelphia Chromosome Test is a molecular diagnostic test designed to detect the presence or absence of the BCR-ABL fusion gene, which results from the Philadelphia chromosome translocation (t(9;22)(q34;q11)). This genetic abnormality produces an abnormal tyrosine kinase protein that is a hallmark of certain leukemias, especially:
• Chronic Myeloid Leukemia (CML)
• Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
Using polymerase chain reaction (PCR), the test amplifies and identifies the fusion gene transcripts in blood or bone marrow samples, giving a qualitative result (positive/negative).

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    Description

    Why It’s Done:

    This test is performed to:
    • Confirm diagnosis of CML or Ph+ ALL by detecting the Philadelphia chromosome
    • Identify the presence of BCR-ABL fusion gene in patients with suspected leukemia
    • Assist in disease classification and prognosis
    • Guide initial treatment decisions, especially regarding targeted therapy with tyrosine kinase inhibitors

    Preparation:

    • No special preparation is necessary.
    • A blood sample or bone marrow sample will be collected.
    • Inform your healthcare provider about any recent treatments or medications.
    • No fasting or dietary restrictions are required.

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