Bcr – Abl Breakpoint – Pcr

The BCR-ABL Breakpoint PCR Test is a molecular diagnostic test that detects the presence of the BCR-ABL fusion gene resulting from the Philadelphia chromosome translocation (t(9;22)). This fusion gene produces an abnormal tyrosine kinase protein involved in the development of certain leukemias, primarily:
• Chronic Myeloid Leukemia (CML)
• Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
The test uses polymerase chain reaction (PCR) to amplify and detect the specific fusion gene transcripts from blood or bone marrow samples. It helps confirm diagnosis, monitor disease progression, and assess response to therapy.