B – Cell Clonality For Igh

5,000.00

The B-Cell Clonality for IGH (Immunoglobulin Heavy Chain) Test is a molecular diagnostic test used to detect clonal rearrangements in the immunoglobulin heavy chain gene (IGH) of B lymphocytes. This test helps determine whether a population of B-cells is monoclonal (originating from a single cell clone) or polyclonal (normal, diverse population).
Clonality testing is performed using PCR-based methods to amplify IGH gene segments and analyze their patterns. It is widely used in diagnosing B-cell lymphomas and leukemias, where clonal B-cell proliferation is a hallmark.

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    Description

    Why It’s Done:

    This test is done to:
    • Diagnose and classify B-cell lymphoproliferative disorders, such as:
    o Non-Hodgkin lymphoma
    o Chronic lymphocytic leukemia (CLL)
    o Other B-cell malignancies
    • Differentiate between benign/reactive lymphoid hyperplasia (polyclonal) and malignant lymphoma (monoclonal)
    • Monitor disease progression or relapse after treatment
    • Assist in evaluating unclear lymph node biopsies or blood/marrow samples

    Preparation:

    • No special preparation such as fasting is required.
    • A sample of tissue, blood, bone marrow, or other relevant specimen is collected depending on the clinical indication.
    • Inform your healthcare provider about any recent treatments or medications.
    • The procedure for sample collection depends on the source (e.g., biopsy, blood draw