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Hla A,B,C (Class I Antigens)

₹6,000.00

15 minutes
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This test identifies specific variants (alleles) of the Human Leukocyte Antigen (HLA) Class I genes: HLA-A, HLA-B, and HLA-C.
• These genes are part of the major histocompatibility complex (MHC) Class I system, playing a key role in the body’s immune response.
• The test is typically done using molecular techniques such as PCR (Polymerase Chain Reaction) or SSO (Sequence-Specific Oligonucleotide) typing.
• The results determine an individual’s HLA type, which is unique to each person (like a fingerprint).

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    Description

    Why It’s Done (Purpose):

    1. Organ and Bone Marrow Transplant Compatibility:
    o To match donors and recipients for organ or stem cell transplantation.
    o Close HLA matching reduces the risk of graft rejection and graft-versus-host disease (GVHD).
    2. Disease Association Testing:
    o Certain HLA types are linked with specific autoimmune diseases, such as:
     HLA-B27 → Ankylosing spondylitis
     HLA-B51 → Behçet’s disease
     HLA-A3 → Hemochromatosis (in some cases)
    3. Paternity and Identity Testing (in some cases):
    o HLA typing may be used in forensic or family relationship testing, though less commonly now due to DNA testing.
    4. Research and Pharmacogenetics:
    o To study genetic predispositions to drug reactions or immune-related conditions.

    Preparation Guidelines:

    • No special preparation is required.
    • A blood sample is drawn from a vein.
    • Inform your healthcare provider if:
    o You have had a blood transfusion or organ transplant recently.
    o You are currently on any immunosuppressive therapy, as it may influence the timing of the test or interpretation of results.

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