Description
Why It’s Done:
The HSV-1 PCR Qualitative test is ordered to:
• Diagnose an active HSV-1 infection, especially when sores or lesions are present.
• Confirm HSV-1 as the cause of oral lesions, herpes keratitis (eye infection), or herpes encephalitis (brain infection).
• Detect the virus in newborns or immunocompromised individuals.
• Differentiate HSV-1 from HSV-2 in cases of genital infections.
• Support diagnosis when antibody tests (IgG/IgM) are inconclusive or not useful (e.g., early in the infection).
This test is more accurate during active outbreaks when the virus is shedding.
Preparation:
• No special preparation is needed from the patient.
• A sample collection will be done depending on the affected area:
o Lesion swab: the most common method
o CSF or blood draw: if systemic or neurological symptoms are present
• Inform your doctor if you are currently using antiviral medications, as this may affect viral detection.


