Description
Why It’s Done:
The CD5 and CD19 – Percent Test is performed for several reasons:
• Diagnose and monitor B-cell and T-cell malignancies, such as B-cell lymphoma and chronic lymphocytic leukemia (CLL), where abnormal populations of CD5+ and CD19+ cells are commonly seen.
• Evaluate immune system function, especially in conditions where there may be a disruption in normal T-cell or B-cell populations (e.g., autoimmune diseases, immune deficiencies, or inflammatory disorders).
• Assess the presence of abnormal cell populations in suspected leukemias or lymphomas, where specific cell markers such as CD5 and CD19 can help distinguish between cancerous and non-cancerous cells.
• Monitor treatment responses in patients with B-cell or T-cell cancers, as changes in CD5 and CD19 expression may occur with disease progression or remission.
• Differentiate between normal and malignant B-cells, as CD5+ B-cells are a common finding in some B-cell lymphomas, especially in CLL.
Preparation:
• No fasting or special preparation is required for this test.
• Inform your healthcare provider about any medications (e.g., immunosuppressive drugs, chemotherapy) that may affect T-cell or B-cell populations.
• A blood sample is collected from a vein in your arm, or tissue samples may be used in certain cases, and the analysis is performed using flow cytometry
