Description
Why It’s Done
1. Detect Medullary Thyroid Carcinoma (MTC)
• Primary purpose of the calcitonin test
• Helps diagnose, monitor, or screen for medullary thyroid cancer, which originates from the C cells of the thyroid
2. Monitor Treatment for MTC
• Used to assess how well treatment (e.g., surgery or therapy) is working
• Helps detect recurrence of the disease
3. Screen High-Risk Individuals
• For people with a family history or known RET gene mutation associated with multiple endocrine neoplasia type 2 (MEN 2), which includes a high risk of medullary thyroid cancer
4. Evaluate Thyroid Nodules
• If a thyroid nodule is found, measuring calcitonin can help determine if it’s related to MTC
Preparation
1. Fasting
• Fasting is usually not required, but follow your healthcare provider’s instructions.
2. Medications
• Inform your doctor about all medications, supplements, and over-the-counter products you take. Some substances can influence calcitonin levels, including:
o Proton pump inhibitors (PPIs)
o Beta blockers
o Glucocorticoids
o Calcium or vitamin D supplements
Do not stop any medication unless advised by your doctor.
3. Stimulation Test (If Ordered)
• In some cases, a calcitonin stimulation test may be performed using pentagastrin or calcium infusion to provoke calcitonin release.
• This test requires special preparation and supervision and is usually done in a hospital or clinic setting.
