Bcr – Abl Translocation – Fish

6,000.00

The BCR-ABL Translocation Fluorescence In Situ Hybridization (FISH) Test is a cytogenetic test used to detect the BCR-ABL gene fusion caused by the Philadelphia chromosome translocation (t(9;22)(q34;q11)) in cells. FISH uses fluorescently labeled DNA probes that bind specifically to the BCR and ABL gene regions on chromosomes, allowing visualization under a fluorescence microscope.
This test can be performed on blood, bone marrow, or other tissue samples and helps identify the presence and proportion of cells carrying the BCR-ABL fusion.

Description

Why It’s Done:

The test is used to:
• Confirm diagnosis of Chronic Myeloid Leukemia (CML) and Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
• Detect the Philadelphia chromosome when conventional cytogenetics is inconclusive or unavailable
• Monitor residual disease and response to therapy in patients under treatment
• Guide treatment decisions, especially regarding targeted therapies like tyrosine kinase inhibitors

Preparation:

• No special preparation is required.
• A blood sample or bone marrow aspirate will be collected.
• Inform your healthcare provider of any recent treatments or medications.
• No fasting or dietary restrictions are necessary before the test.